|
KMID : 1188320170110060852
|
|
Gut and Liver
2017 Volume.11 No. 6 p.852 ~ p.859
|
|
|
Role of Shear Wave Elastography in Evaluating the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B
|
|
Jeong Jae-Yoon
Sohn Joo-Hyun
Sohn Won
Park Chan-Hyuk
Kim Tae-Yeob
Jun Dae-Won
Kim Yong-Soo
Jeong Woo-Kyoung
|
|
|
Abstract
|
|
|
Background/Aims: To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).
Methods: We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE.
Results: The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (≥50 years) and higher LS value (≥10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (≥10 kPa) than in those with lower LS values (<10 kPa) (p=0.001).
Conclusions: Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.
|
|
|
KEYWORD
|
|
|
Elastography, shear wave, Liver stiffness, Hepatitis B, chronic, Carcinoma, hepatocellular
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|